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The Question Is…Does Menopause Ever End?

MatureHealthyFemale_lying on bedIn short, NO! The menopause never ends. It’s just the beginning.

It always astounds me when I hear women say, “I’m over the menopause.” That’s because in reality, the menopause never ends. It’s just the beginning.

Yes, the more disruptive symptoms, such as hot flushes/flashes, mood swings, weight gain, depression, sleep disorders, and others, do subside as our body adapts to the new hormonal environment (one of low hormone production). Incredible but true – our body adapts to this situation. But the more serious and deleterious issues just keep on chugging along. What do I mean by that?

Let’s take a look.

The Three Stages of Change

There are three phases of menopause, hmm…maybe four if we count premenopause (before perimenopause and menopause! 🙂 ) When we are still considered to be in our reproductive years.

All three have a name because all three exist.

Perimenopause

Perimenopause is the ‘symptom stage’ where we get all cranky and become another person really. Or the majority of us do anyway. Not the person we used to be. We don’t feel good. This is the stage in which our body is suffering from a sudden and drastic loss of female hormones. Our body is now in a hormonal revolt and is determined to let us know by way of symptoms.

Basically, our body is in hormonal-starvation-mode, it is suffering withdrawal symptoms. The body needs its hormones back to allow us to function correctly and rid us of all those life-destroying issues. And to allow us to return to the ‘us’ we once were.

This is when we should start thinking about embarking on a programme of bioidentical hormones restorative therapy (BHRT). Imagine the peaceful and symptom-free life you would have!

Perimenopause usually lasts from 5 to 10 years, starting at about age 45. This is an approximation of course. It can start before, last longer or start later and finish sooner. Everyone is different.

Menopause

Menopause is the, ‘you no longer have a period and haven’t had one for over 12 months. 1 year, in other words’, stage. And where your symptoms start to ease. Our body is becoming used to living without hormones. It has adapted, even if it doesn’t want to, it has to.

When we are born, we are born with 1 to 2 million undeveloped eggs in our ovaries and, by the time we reach puberty and start menstruating, approximately only 300,000 immature egg cells (or follicles) remain. Following this, an average of 600 follicles die per month, which are not replaced. By the time we reach menopause, there are no eggs left. As eggs are the main producer of female hormones, this is why we slowly become deficient (in female hormones).

Menopause means the end of our reproductive life as we know it. You can no longer make babies. We have no eggs left and without eggs there will be no oestrogen production and consequently, this leads to no more progesterone production either.

Believe it or not the brain doesn’t like this scenario, it likes to think we are still reproductive. Yes, it may sound crazy but it’s true. The brain gets confused and thinks we are of no use anymore. It believes we are only here to reproduce. Biologically speaking we are here to perpetuate the species (of course, we know better :)). We know we still have a lot to give. Unfortunately, though, the brain isn’t convinced about this. Luckily, we can now do something about it…we have an option. BHRT is that option.

Bioidentical hormones, ‘the miracle molecule’, help reset the brain into thinking all is well again. They kind of trick the brain. Life will continue as before, or maybe even better than before! Even if we are no longer capable of making babies. Hormones nourish the brain and the body and keep it working at optimal.

Post-menopause

So what happens after menopause, when symptoms of perimenopause have subsided and we no longer have a period? Does this mean the menopause has ended, that everything goes back to normal and life just starts all over again? Was the perimenopause just a hiccup? Was menopause just a message telling us we could no longer reproduce? Not exactly.

Yes, it is true that the majority of menopausal women find that symptoms such as hot flushes, night sweats, sleeping difficulties, mood swings, etc are transitory. And last only as long as it takes the body to adapt to the lower hormone levels. But don’t kid yourself, the menopause is not over. There are other menopausal health issues that are happening within the body. We are talking post-menopause here.

In fact, more important and permanent changes such as drying and thinning skin and vaginal membranes, dry eyes, foggy memory and a decreased urinary tract tone, to name a few, are the next step in this body-change. Basically, this is your body breaking down, sad to say but true. This is your body talking to you. You need to listen to it and take action. We do have a choice now, an alternative…an option!

As time passes, other developments such as heart disease, osteoporosis, cholesterol disorders, cancers, diabetes, and cognitive problems all become more apparent. All of these health issues are known as age-related diseases. They are related to ageing and hormonal loss. Our repair molecules are missing. Hormones play a critical role in repair and regeneration because they are the most comprehensive messaging machine in the human body.

They are the human network of health. They are what keep us in one piece. They are what make us work. With missing or low levels we will feel it. In truth, low hormone levels put an enormous stress on the entire body. Imagine putting petrol in a diesel car…same concept. It won’t work very well. Chug chug! Then it grinds to a halt.

With low hormone levels the body cannot repair or regenerate itself as fast as it once did, and certainly, will not function properly. It will start to ‘chug’ and slow. You see this every day on the streets. Just compare a young woman of 20, in her prime, to a woman of 50, then to a mature woman of 80. Do you notice the ‘chug syndrome’?

This is what happens to the body post-menopause. You don’t feel it like you feel the initial symptoms in perimenopause because it’s moving so slowly, but the body is giving us other indicators now. Your body is struggling. It’s running on low. It’s in breakdown mode.

I am not saying that bioidentical hormones stop us from ageing totally, we all age and we all die. But they definitely slow and ease the ageing process. We age more gracefully. They make us feel and look good. They help us avoid unnecessary pain and discomfort. We can choose how we want to age. In illness or in health. We can hold back age-related and chronic diseases…honest we can. We now have a new template for change. Let’s embrace this change, this new way of ageing. We no longer have to accept the traditional way of ageing, we CAN make ageing good.

We can choose whether to take bioidentical hormones or not. They are truly the key to optimal health and optimal ageing.

Please don’t kid yourself that the menopause ends. Just because your symptoms have subsided does not mean you are no longer in menopause. In fact, as you’ve now understood, you are seriously in menopause…big time. The trick is to keep your body, brain and immune system strong. All of which bioidentical hormones do.

Why am I telling you this?

Why? Because I truly want to help you understand that we DO NOT have to sit quietly and suffer the symptoms of menopause, or in the long-term, the consequences of post-menopause (body breakdown), which brings with it turmoil and the age-related diseases mentioned above, and many many others.

When we restore our hormones we can avoid the symptoms of perimenopause, curb chronic disease, and slow the ageing process. Isn’t that just great. This is for real. I know it myself. I see and feel it every day. I could not live without my hormones. I am vibrant, energetic, focused, positive, happy, sensual, sexy, and enjoy the things in life I always did.

I am sixty-one this year but my biological age is 45 years. How’s that for trumps? I have been on bioidentical hormones for more than 12 years now. I love my life! Embracing BHRT was the best thing I ever did. I am happy and look forward to even better things to come every single day.

I am straight and upright, not bent and crooked. My body is strong, and my mind is the best it has ever been. I am living the optimal life. You can too.

My last tip of the day

If you are considering taking bioidentical hormones (BHRT) make sure you go to an expert. Hormones are safe and work efficiently when prescribed by an expert doctor. BHRT, if not followed and prescribed correctly, can be just as detrimental as synthetic hormones. It is important to find a doctor qualified in this sub-speciality. Always check him/her out! Ask where and who trained them.
Bioidentical hormones aid us in ageing with style, grace, vibrancy and energy, and in maintaining that easy movement of youth. That clarity of thinking, sexuality, sensuality, and zest. What more could you ask for? When we are healthy, feel and look good, each stage of life is wonderful.

For Your Information
If you would like a more in-depth look at menopause, how your body works and exactly what BHRT is check out my book, “The Menopause Cure – Hormonal Health”. I know you’ll enjoy it. It’s an easy read and life changing. Live your life to the fullest.
If you are looking for a qualified BHRT doctor click this link, or drop our team a message or email us – we’re here to guide you.

Your health is our priority.

To Your Health 🙂

Jill xx

Bioidentical Hormone Restorative Therapy (BHRT) – Let’s Start At The Beginning.

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BHRT_Ipad

Not All Hormones Are Prescribed Equally

Not all hormone therapies that are prescribed and taken are created equally. HRT and BHRT are two very different therapies.

Unfortunately, all hormones in any form are considered a controversial topic. This, of course, would be due to the outcome of the Women’s Health Initiative (WHI) study which was halted ahead of schedule, in 2002, after it was found that HRT (hormone replacement therapy), a combo drug of synthetic oestrogens and progestins commonly known as PremPro, increased the risk of both heart disease and breast cancer.

Since the WHI study, both synthetic and bioidentical hormones have been bundled together as ‘bad’ and disease-causing.

This, of course, is totally untrue.

The Importance Of Understanding The Difference Between HRT And BHRT

It is important for everyone to understand the difference between these two forms of hormonal therapies – synthetic and bioidentical – and to have the correct information, otherwise, we will never get over this misconception of bad meets bad.

The major difference between bioidentical hormones and synthetic hormones is that synthetic hormones (HRT) set-up new reactions in the body that it is unfamiliar with. In short, they declare war with our physiology (in other words, body-balance and health); they mess with it! This is largely due to the fact that they are synthetic and the body and brain cannot quite get around that fact. The body/brain set-up gets confused when something ‘non-natural’ is put into it.

The body doesn’t produce synthetic hormones, never has done, and never will do. I am wondering why then, should we replace our declining hormones with alien or counterfeit ones – ones that have never ever existed in the body? And ones that have been seen to create detrimental and lethal health issues. It just doesn’t make sense. Instead, we should be restoring the missing hormones with bioidentical ones, identical to those produced in the body. Ones that do not cause health issues but rather enhance our health.

Bioidentical hormones restore normal physiological pathways with optimal body response. In other words, they work, they make us feel well. They calm our symptoms’, and at the same time slow the ageing process. They create harmony within the body – not disharmony! That is because the body/brain set-up understands them with great ease.

Hormones – The Human Network of Health

Hormones are miracle molecules that are naturally produced (endogenous) in the body and keep us alive and functioning. They are precious – we have been blessed with them. If we want to remain healthy, vibrant, positive and young, we need to keep them in the body at the correct levels and ratios.

With age, our hormones decline. When hormones decline, our health, both physical and mental, also declines, leaving us in a weak position. Maintaining optimal hormone levels is key to keeping us young, beautiful and sexy. And it is the most independent factor for a healthy, strong and vibrant immune system. And for keeping our hearts, brains, bones, joints, and bodies functioning correctly…at optimal.

Hormone ratios are very important to body health and maintenance. It’s not just the levels of hormones that counts but the ratios between these hormones. Hormones ratios such as oestrogens to progesterone and cortisol to DHEA, which greatly impact our health.

Hormones are messaging machines that interact with each other to literally form ‘a human network of health’ – they are, in fact, what helps us ‘keep it all together’! With a decline, we begin to fall apart slowly but surely. This is when the first signs or symptoms of ageing become apparent: withered, wrinkled and thinning skin; loss of muscle tone; weight gain; low sex drive; low mood; aching joints – these are just a few from a long list of health issues that occur with a hormonal decline. Menopause, in truth, is the beginnings of the ageing process, like it or not. This, of course, is also valid for men – they don’t get away scot-free either. They suffer hormonal decline just as we do, but in a slower and more gentle way.

When we restore declining hormone levels with bioidentical ones, we ‘keep it all together’, slow the ageing process, hold off chronic disease, and regain and/or maintain our health. It is never too early to start – the sooner, the better. We now have an option.

Let’s Take a Look at Bioidentical Hormones

Bioidentical hormones are an exact copy of the hormones produced in the body, they act and are read by the body exactly as our own. They come from soya and wild yam, and other plant extracts that are biosynthesised in a lab to become an exact copy of the human hormone. We are so lucky to have these miraculous molecules within our reach these days.

They are life-giving molecules that protect and enhance our declining and maturing health. They do not challenge the body in any shape or form – they are safe and efficient when prescribed by an expert doctor. BHRT, if not followed and prescribed correctly, can be just as detrimental as synthetic hormones. It is important to find a doctor qualified in this sub-speciality. Always check him/her out! Ask where and who trained them.

Bioidentical hormones aid us in ageing with style, grace, vibrancy and energy, and in maintaining that easy movement of youth. That clarity of thinking, sexuality, sensuality, and zest. What more could you ask for? When we are healthy, feel and look good, each stage of life is wonderful.

I admit, there is no magic bullet for the so-called ‘fountain of youth’ but, if I were to tell you that bioidentical hormones were also the golden key to better sex, a leaner body and a more youthful skin, would you believe me? You’d better! Typically, women taking bioidentical hormones look and act 10 to 15 years younger than women who don’t. And did I mention weight loss and thicker hair too?

For Your Information

If you have read my book, “The Menopause Cure – Hormonal Health”, and/or checked out my website, you will have understood why it is important to restore your body with bioidentical hormones. And the huge benefits these natural molecules provide. Life is fun again!

If you are looking for a qualified BHRT doctor click this link,drop our team a message or email us – we’re ready to help.

Your health is our priority.

To Your Health 🙂 xx

Why Are You Not Taking Bioidentical Hormones?

Peri_wordswhite abckgrouI often ask myself why every menopausal woman (including perimenopausal and postmenopausal women), isn’t on bioidentical hormones. A therapy known as bioidentical hormone restorative therapy (BHRT). To me it is a phenomenon that just doesn’t fit. Something is wrong here. I’m perplexed, considering the immense benefits they can give you, both short-term and long-term.

Is it because they don’t know enough about this therapy? Is it because they’ve been conned into thinking it is dangerous or, that they just don’t work. Of course they work!

Could it be because they have never heard of them before? It is true that we don’t often hear people, including doctors, debating or talking about bioidentical hormones in Europe. And when we do it’s usually negative, strangely enough. Even if it has existed for over 30 years in America.

That’s basically a long-term study right there for you. We need studies to give us scientific proof, facts, and truths. Long-term studies are the best for bringing out the truth and to see if the subject in question is valid or not, whether it be a medicine or a plastic implant for joints. This long-term study on BHRT, that I put before you is definitely a resounding YES! It works. And how it works!

To give you a better understanding of bioidentical hormones, and body physiology, let’s take a quick look.

Hormone Decline

Hormones decline with age, starting at about age 30. The decline is slow until we reach about 40ish, let’s say 45, where the majority of women enter menopause. And where there is a sudden and drastic drop in female hormones. This phase is known as perimenopause, and usually lasts from 5 to 10 years. Perimenopause is where women begin to suffer symptoms, due to the hormonal decline, such as hot flushes/flashes, mood swings, brain fog, aching joints, sleepless nights, weight gain, and many more, that I am sure you are all aware of.

When our hormones decline many women lose themselves…or at least I did. I was no longer the person I had once been. I lost my lust for life, my positivity, my stamina and Jill herself. She was gone. She has of course since returned, and better than ever. Thanks to BHRT.

When there is a hormonal imbalance, havoc erupts within the body and trouble begins. Basically, when hormones decline it creates problems within the endocrine system (where hormones are made) and follows on to other body systems, including immune, cardiovascular and gastrointestinal systems. You may have noticed you don’t digest foods as easily as you once did. That’s a sign (or even symptom)…listen to it!

If you want to be healthy, both physically and mentally, and continue to be healthy you need to optimise and balance hormone levels so as to support optimal physiology. Hormones are vital for repair and are the most powerful agent in the regulation of optimal physiology. Physiology simply refers to a healthy, well-functioning body and mind.

What Your Local GP Usually Has to Say

When symptoms occur and perimenopause hits, women usually go to their local GP and ask if they are in menopause…of course you are. Your age suggests it and your symptoms are telling you you are.

Your GP will most likely offer you HRT (synthetic), antidepressants, and sleeping tablets. Pat you on the back and tell you, all will be ok, and that it will pass. Hmmm…I’m not so sure about that! In fact, it doesn’t pass, hormonal decline only gets worse.

Your symptoms will pass once your body has adapted to its new hormonal environment…low hormone production. But hormonal decline doesn’t go away unless you do something about it…like restore them. It only gets worse. We are now moving towards total degradation and chronic disease, but that’s for another discussion.

Your symptoms by the way, are actually withdrawal symptoms, due to lack of hormones (hormonal decline). It’s a hormonal revolt. It only makes sense the body is going to suffer if it is missing the major messaging molecule. Yes, hormones are our messaging machine. They make us or they break us, simple as that.

Bioidentical Hormones And What They Can Do For You

What are bioidentical hormones? Why are they so good…GREAT really?

Bioidentical hormones are biologically identical to the hormones that are produced in our body. They are identical in molecular structure – hormone replicas. They come from soya, wild yam and other plant extracts. This is one of the reasons they are so well accepted by the body (because they are exact in structure), and therefore, can be used just as our own hormones, for regeneration and repair.

Importantly, they make us feel great…fantastic in fact. They give us our life back. They are miracle-molecules. They nurture the brain and feed the body. One way of looking at it is, they are the body’s endogenous (made in the body) food. When perimenopause is upon us we are in hormonal- starvation mode. Do we really need this when we can restore them so easily?

Hormones are the essence of life itself. They regulate every bodily function: sleep, growth, blood pressure, heartbeat, breathing,– without them we would simply die. They control muscle tone, build bone, make us fat or thin, maintain correct levels of sugar in the blood and tissue, control women’s menstrual cycles, make men males, rule the passage of time and the voyage into menopause.

They make us happy or sad, they make us cry or laugh, they are us. They give us beautiful skin, nails and hair or vice versa. When hormones decline our skin begins to wrinkle and sag before its time. Hair loses its shine and thickness, and nails start to crack and become brittle, or even become soft. That is just a few examples for you.


Hormones and Immune System Support

Another major benefit of optimal hormone levels is they support our immune system and its function. When hormones decline so does our immune system.

We are the ones that make the choices which strengthen or weaken our immune system. Our immune system is the protector of our health and vitality, which enables us to feel good both physically and emotionally. If our immune system is weak we are less able to handle stress and more susceptible to illnesses. When our immune system is suppressed over a long period, we are definitely more likely to suffer from far more serious diseases such as breast cancer, arthritis, autoimmune diseases and more. I am protecting my protector. You? A major component of having a strong immune system is restoring hormone levels.

In short, without optimal levels of hormones our body slows down and becomes inefficient. We then deteriorate at a great rate and age at a faster speed.

Why do that to yourself?

Take this opportunity to live your best life.

If you would like to know more please read my book, “The Menopause Cure – Hormonal Health

To your health

Jill

Telomeres: How to Help Prevent Them from Shortening

In my previous blog, I discussed the importance of telomeres to the ageing process and our bodies. Naturally, telomere length, and their impressive health benefits are now gathering more and more interest… the race is on! How do we preserve telomere length in normal cells, which in turn, sustain healthy cellular youth and functionality?

The Answer? Vitamin Supplementation

Over the last few years, scientists have gathered a tremendous and convincing amount of evidence, demonstrating that one way of supporting telomere health and length is to include a daily regime of certain vitamins in adequate amounts including, B vitamins (including vitamin B12, vitamin B6, and folic acid), vitamin D3, vitamin C, and vitamin E (in particular Gamma-tocotrienol which prevent, and may even reverse telomere shortening), and the vegetable carotenoids, such as lutein and zeaxanthin, high levels of which have been seen to promote significantly longer telomeres.

Fish oils have also demonstrated they can significantly impact telomere length. One study showed that by reducing blood levels of omega-6 fats, and increasing omega-3s (from fish oil), the outcome was increased telomere length. This was due to a reduction of inflammatory molecules (cytokines) and oxidative stress, which was brought on by higher levels of omega-3s in relation to the pro-inflammatory omega-6s. There is a specific ratio between omega-6s and omega-3s that has to adhered to, to help prevent excess inflammation and for us to remain healthy. It is important to have both these omegas present in the body, so long as they are in the correct ratios.

An Important Note for Women

Women who consume a diet lacking in antioxidants tend to have shorter telomeres and present a moderate risk of developing breast cancer. On the other hand, a diet rich in antioxidants such as vitamin E, vitamin C, and beta-carotene have been linked to longer telomeres and a lower risk of breast cancer.

I mentioned previously about hormone deficiencies and decline, and the influence they have on the shortening of telomeres. Hormones decline with age, but supplementing with bioidentical hormones can aid telomere length. Oestrogen – 17 beta oestradiol – and testosterone activate telomerase which plays a key role in telomere length. However, estrogen blockers such as those given to women who have been found to have cancer, turn off or inhibit telomerase, as do androgen (synthetic male hormone) blockers.

So to help maintain telomere length… remember to take your antioxidants and vitamins, and for an even better outcome… bioidentical hormones as well!

References

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Chiappori AA, Kolevska T, Spigel DR, et al. A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer. Ann Oncol 2015;26(2)354-62.

Pusceddu I, Herrmann M, Kirsch SH, et al. One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation. Eur J Nutr. 2016.

Xu Q, Parks CG, DeRoo LA, et al. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009;89(6):1857-63.

Shin C, Baik I. Leukocyte Telomere Length is Associated With Serum Vitamin B12 and Homocysteine Levels in Older Adults With the Presence of Systemic Inflammation. Clin Nutr Res. 2016;5(1):7-14.

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Jennings BJ, Ozanne SE, Dorling MW, Hales CN. Early growth determines longevity in male rats and may be related to telomere shortening in the kidney. FEBS Lett. 1999 Apr 1; 448(1):4-8.

Jennings BJ, Ozanne SE, Hales CN. Nutritional, oxidative damage, telomere shortening,  and cellular senescence: individual or connected agents of aging? Jennings BJ, Ozanne SE, Hales CN. Mol Genet Metab. 2000 Sep-Oct; 71(1-2):32-42.

Xiong S, Patrushev N, Forouzandeh F, et al. PGC-1alpha Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases. Cell Rep. 2015;12(9):1391-9.

Pusceddu I, Farrell CJ, Di Pierro AM, et al. The role of telomeres and vitamin D in cellular aging and age-related diseases. Clin Chem Lab Med. 2015;53(11):1661-78.

Zhang D, Sun X, Liu J, et al. Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. Arterioscler Thromb Vasc Biol. 2015;35(1):71-8.

Harley CB, Liu W, Flom PL, et al. A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response. Rejuvenation Res. 2013;16(5):386-95.

Borras M, Panizo S, Sarro F, et al. Assessment of the potential role of active vitamin D treatment in telomere length: a case-control study in hemodialysis patients. Clin Ther. 2012;34(4):849-56.

Makpol S, Zainuddin A, Rahim NA, et al. Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals. Planta Med. 2010;76(9):869-75.

Tanaka Y, Moritoh Y, Miwa N. Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes. J Cell Biochem. 2007;102(3):689-703.

Makpol S, Abidin AZ, Sairin K, et al. gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxid Med Cell Longev. 2010;3(1):35-43.

Sen A, Marsche G, Freudenberger P, et al. Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study. J Am Geriatr Soc. 2014;62(2):222-9.

Kiecolt-Glaser JK, Epel ES, Belury MA, et al. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun. 2013;28:16-24.

Gonzalez-Suarez I, Redwood AB, Grotsky DA, et al. A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair. Embo j. 2011;30(16):3383-96.

Liu JJ, Prescott J, Giovannucci E, et al. Plasma vitamin D biomarkers and leukocyte telomere length. Am J Epidemiol. 2013;177(12):1411-7.

Kim YY, Ku SY, Huh Y, et al. Anti-aging effects of vitamin C on human pluripotent stem cell derived cardiomyocytes. Age (Dordr). 2013;35(5):1545-57.

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Farzaneh-Far R, Lin Jue, Espel ES, Harris WS, Blackburn EH, et al. Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease. Jama 2010 Jan 20;303(3):250.

Masood A. Shammas. Telomeres, Lifestyle, Cancer and Aging. Curr Opin Clin Nutr Metab Care. 2011 Jan; 14(1): 28–34.

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Telomeres: Is Your Body’s Fuse Burning Out?

Could Your Body’s Fuse Be Burning Out?

Telomeres is a “hot subject” these days as they are considered to be an important factor in the ageing process, and although ageing is multifaceted, a host of research demonstrates that telomere length is as an excellent biomarker for ageing at the cellular level. The shortening of telomeres, over time, accelerates cellular ageing, however there are various nutrients that assist telomere repair and help maintain telomere length, that have proven health benefits.

What Exactly Are Telomeres?

They are often compared to the burning fuse; like this fuse, telomeres at the end of our chromosomes, steadily but surely shorten every time a cell replicates itself. Telomeres are a ‘time-bomb’ that hold the key to biological ageing; they are small strands of DNA code in our genes which control ageing and cell replication. In short, they help dictate how fast or slowly we age. Once they have reached a ‘critical point’ of shortness, cellular replication can no longer take place, which leads to ageing (senescence) of the cell and finally death, sometimes known as the “Hayflick limit process”. Ageing cells are not needed in the body and no longer contribute to efficacious tissue upkeep. And, in fact, telomere length is a very useful biomarker of cellular ageing.

Cells contain an enzyme (enzymes are special chemicals which speed up the body’s processes. Enzyme function declines with age) known as telomerase, which has the function of adding fresh new DNA to the ends of telomeres, assisting in keeping them long enough to support and maintain cellular health and activity.

What Circumstances Activate, Determine and Accelerate Telomere Shortening?

At every turn, we are faced with an internal (within our body) battle against negative forces. The eternal, endless and internal battle, wages war on our molecules, our cells, our entire body, as those forces actively work to destroy them. Our enemies in this war include: oxidation, glycation (a process that is damaging and toxic to the body), abnormal methylation (can lead to an increased risk of certain cancers, heart disease, stroke, neurodegenerative diseases, and other chronic issues.), inflammation, and DNA gene mutation. At the same time, we also have to face external influences; environmental toxins, unhealthy diet, overeating (a restricted diet has been associated with significantly longer telomeres and longevity), lack of exercise, smoking, nature of work/profession, stress, hormone and vitamin deficiencies. All of these trigger the shortening of telomere length.

At every level, life and longevity is a balance of factors. Just as love is a balance of growing, learning and understanding each other; a balance between freedom and trust: ageing is a balance between entropy and defense; degradation and restoration. We must learn to come together and understand it, and learn how we can protect our telomeres and therefore, our lives and our longevity.

Why are Telomeres More Important as we Age?

Our body is so intricately designed that the human infrastructure instinctively defends us from an attack. From the top and at every level, the body has specific systems in place to protect, minimise, restore and repair damage. But as we age, from approximately 30 years, the human infrastructure and its systems begin to break down. As the years and decades pass, the breakdown picks up speed, shifting gears from first, to second, and finally sixth gear.

Our body is no longer able to repair itself as it once did. Cells can’t recycle as well as they once did, and as a result, the damage in our body increases. We now get a shift towards more damage and decay (known as catabolic) from restore and repair (known as anabolic). Age-related defects in metabolism equate to increased pathology (disease). When the body slows, the restore and repair systems in place decline and, at the same time, the pace of telomere shortening increases. The erosion of telomeres plays a role in ALL diseases. Shortened telomeres are found in individuals with age-related disorders including neurodegeneration, cardiovascular disease, diabetes, and cancer.

In my next blog on Telomeres, I will explain how you can help to maintain their length with vitamin supplementation.

References

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Chiappori AA, Kolevska T, Spigel DR, et al. A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer. Ann Oncol 2015;26(2)354-62.

Pusceddu I, Herrmann M, Kirsch SH, et al. One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation. Eur J Nutr. 2016.

Xu Q, Parks CG, DeRoo LA, et al. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009;89(6):1857-63.

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Xiong S, Patrushev N, Forouzandeh F, et al. PGC-1alpha Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases. Cell Rep. 2015;12(9):1391-9.

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Makpol S, Abidin AZ, Sairin K, et al. gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxid Med Cell Longev. 2010;3(1):35-43.

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What is the difference between ‘Biological vs Chronological Aging?

Why does Elle Macpherson (age 50) look more like 30 and Helen Mirren (70) look like she is 50?

What is the difference between ‘Biological vs Chronological Aging?

Sergey Dzugan, MD, PhD, a former heart surgeon, professor, published cancer research scientist and world leader in Restorative Medicine is asked what is the difference between ‘Biological vs Chronological Aging?

Obviously genes, environment and lifestyle are very important to your health but “restoring the most powerful agents, hormones is what really matters. As Dr Dzugan explains, it is the hormones who are really in charge.” Watch Dr Dzugan explain why not everything should be treated by drugs, we need to help the body. Want to know more? Watch the video and read my book, The Menopause Cure; Hormonal Health, written with Sergey Dzugan, MD, PhD.

Transcript

For the readers, what is the difference between chronological and biological age?

A simple way to explain it. Chronological age is how many years you have spent on this earth. Biological age is a complex set of signs that show (in how you look) what is going on with your body, your physiology, environment and biochemistry. So – many people who say “I am 55” (but they look like 75). And the opposite, some people who are 75 who look like 55.

What are the major contributing factors that would cause a person to have a biological age older than their chronological age?

They are several factors. Environment plays a big role, what you eat, diet and exercise. But, the problem is, we can stand on our head, drink carrot juice and do a lot of exercise and use any kind of diet. But unfortunately, until you restore hormones you will get decline. Hormones play a crucial role in keeping you metabolism in good shape. As soon as you lose balance between building hormones and destructive hormones you will start to have problems.

The hormone balance (or lack of) is the primary reason a person would have an older biological age?

You can do excessive exercise, have a healthy lifestyle and be a pure vegetarian but nothing will work or help until you restore youthful levels of the most powerful agents, hormones. They are in charge, they communicate with each single cell.

Disease then is a consequence of an imbalance of hormones… which is a major factor in biological aging?

Yes, that is correct. If you take the main causes of death in the United States, first two place belong to heart disease and cancer. This problem usually happens after age 40. More than 95% of people with Cancer or Heart Disease are over the age of 40, the age in which our hormones take a sharp decline. Talking about homeostasis, our body trys to fix immediately if we have any imbalances anywhere, but when you do not have enough of these building forces (hormones) you start to decline.  Hormone levels are the main cause of the body’s deterioration. Your metabolism is really slow, your absorption is really slow. That is why we talk about physiology of medicine because not everything should be treated by drugs. We need to respect what our body does.